Ligandrol ( LGD-4033): Benefits & Side Effects (Update August 2019)

Ligandrol, also known as LGD-4033, is classified as a selective androgen receptor modulator (SARM). It was first formulated by ligand pharmaceuticals, hence its name. Since then, it has been undergoing several developmental processes and clinical tests by Viking therapeutics
As a SARM, it is seen as an effective treatment option for a variety of bone injuries and muscle wasting illnesses. Its development is also meant to address conditions such as aging and osteoporosis. Most credible scientific studies also suggest that the drug can work as an appropriate therapy for cancer and even Aids.

Although it’s still under various stages of development, it has become quite popular for professional athletes such as bodybuilders, who claim that it works exceptionally well in muscle growth and strength. It’s said that unlike steroids, LGD-4033 comes with minimal, to zero side effects. Hence there is never potential harm to the vital organs of the body such as the liver and prostate.

How It Works

The drug works the same way as other SARMs, by binding to androgen receptors in the muscles as well as bones. Therefore there is no way it can travel in the bloodstream and onto the vital organs such as the liver and kidneys to cause harm as steroids do.

Once the drug is introduced in the system, it raises high anabolic activity in both the muscles and bone structure. This immediately arrests any muscle and bone wasting processes. According to several trials, individuals using the drug exhibit lean muscle mass.

There is also an evident decrease in body fat and an overall sense of well-being. The drug also accelerates healing processes in affected individuals. Scientists, therefore, think LGD-4033 is a timely intervention for the elderly, muscle degeneration atrophy, and in the recovery of hip fractures.

Some of the Potential Uses For Ligandrol

Currently, the drug is being researched as an effective treatment option for the following:

Treatment of Muscle Atrophy: Some health conditions such as cancer, Aids, kidney disease among others come with severe weight loss, which affects the muscle structure. This can also compromise the quality of life as a patient undergoes various stages of treatment. 

Also, as people age, their metabolism rates decline, leading to more fat deposits in the body, while even replacing muscle mass. The drug can be used to address such cases by improving muscle mass, but also improving overall body strength and wellbeing of all those concerned.

Cure of Different Types of Fractures and Osteoporosis: LGD-4033 is seen as a potential treatment option for loss of bone density, and cases of hip fractures. The key reason is that the drug usually, starts activating androgen receptors once its administered. Then it works by increasing bone mineral density and lead to the formation of new bones as the response of fractures and any other types of bone injury. 

Menopausal women have always benefited from HRT, but which also carries long-term side effects, including breast cancer. Ligandrol might be what they need to address health issues, including bone and muscle wasting.

Increase in Libido: Although research is still ongoing, it is said that drug interactions can positively impact the regeneration of libido. Since the drug improves muscle strength. This can be directly related to increasing stamina, and hence sexual performance. Recent users have admitted to a general increase in energy levels, wellbeing, and ultimately in matters of libido.

Benefits of LGD-4033

Several advantages associated with this drug are as follows:

  • It comes with minimal side effects.
  • Promotes lean muscle as well as muscle strength.
  • It can heal, strengthen and increase bone mass.
  • Stimulates overall well being.

The drug can be used by a wide range of professional athletes to build muscle strength and optimize body composition.

Dosage cycle of LGD-4033

According to clinical trials, safe dosage and tolerance levels of LGD-4033 stand at 0.1mg, 0.3mg, and 1.0mg.

On the other hand, the drug can be taken in dosages of 10mg for men and 5mg for women who are bodybuilding, cutting, or bulking. The dosage cycle is usually between 8-12 weeks. 

Users can then continue with further post cycle therapy. Although there no indications for long term adverse side effects, it’s always important to consider drug safety and stay within the 12-week cycle.

The drug features a first half-life of between 24-36 hours; this means that users can tolerate a daily dose at once without any side effects. It is also stated that the drug’s concentration usually builds up gradually, with a tolerance of over three weeks. 

Side Effects

Most of the clinical trials indicate that the drug is both safe and effective. For example, when it was administered to a group of healthy men in its very lower doses of 0.1mg, 0.3mg, and 1.0mg, no severe side effects were exhibited. However, the most common side effects were as follows:

  • Dry mouth
  • Headache 
  • Upper respiratory tract infection, not sure if it was related to drug dosage
  • Muscle biopsy-related pain, probably not associated with drug dosage.
  • Individuals who use more than the recommended dose may experience such side effects as:
  • Fatigue
  • Nausea

Meanwhile, most scientists are not sure if some of these minor side effects can be attributed to something else other than LGD-4033, which is seen to be completely safe. Another reason why there is doubt of apparent side effects is that there is super tolerance of the drug among a wide range of trial groups which has always shown similar positive results.


Clinical trials and pilot studies for LGD-4033 place it in the category of very safe and effective drug therapies. Although everything remains inconclusive as of now, the drug is a timely treatment intervention for so many maladies. Conditions like age, muscle atrophy, osteoporosis, cancer, and other diseases can be history with Ligandrol therapy.

The best thing is that LGD-4033 is known to have a high affinity for just muscle and bone androgen receptors, and not for the liver, or prostate or any other delicate organ receptors. This allows it to target only those areas it is supposed to work on, and not interfere with vital organs of the body.

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